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The WHO is about to declare aspartame can cause cancer
(www.vox.com)
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this post was submitted on 08 Jul 2023
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There is a lot of public misunderstanding of the rodent studies that linked aspartame to cancer, which are very flawed and essentially come from a single Italian research group.
There is still no definitive link to cancer risk in humans so I would continue to be skeptical. The maximum recommended safe exposure for aspartame is the equivalent of 12 cans of coke, and the strong effects from the rodent study were using exposure amounts equivalent to 5 times that amount, or 60 cans daily, every day of their life after day 12 of fetal life (i.e. before birth).
Almost anything can cause long-term health risks and toxicity at such massive exposure levels.
https://www.cancer.org/cancer/risk-prevention/chemicals/aspartame.html
Link to the free Pubmed link to one of the original source studies from 2008 so you can see their methodology and the absurdly massive exposure amounts needed to ovserve these effects:
https://pubmed.ncbi.nlm.nih.gov/17805418/
This is why I hate rodent studies. They always up the exposure to whatever they are testing to hyper-extreme limits. Then point their flawed results to the world and declare "See! X causes Y!"
There are even similar rat studies for marijuana that try to link it to cancer as well, despite the fact that zero people have actually died from weed. It's all overblown bullshit.
Dude have you seen how many diet Cokes people drink? Liters and liters daily. Not excessive at all honestly considering LifeTime total exposure
Im a chemist by trade. This is actually chemically very simple. I only looked deeply into Sucralose Splenda. So I'll discuss that
These have Chlorine molecules. A very electrophilic element even in a chemical bond. Meaning it can cause reactions in other molecules very easily. Sucralose has Three Chlorines. If it touches DNA it's bad business man.
I love diet Coke btw lol I could drink 5 gallons right now idk I smoke cigs. But don't sugar coat it
You are saying that sucralose (or a metabolite thereof) could alkylate DNA - and theoretically proteins too - correct? Like what sulfur mustard gas does?
I did a quick search and couldn't find any papers demonstrating a mechanism of action for that, although I skimmed a few that postulated that a dichlorinated hydrolysis product might be the true carcinogenic agent. Do you know of any studies that demonstrate that the alkylation can happen, either in vitro or (ideally) in vivo? Or maybe some better search terms to use, that could be my issue...
I am truly curious about this, I never knew the chemical structure of sucralose until I read your comment and subsequently looked it up.