Check my history but basically no. It's not so hard.
I'm on Debian stable yet place the latest games, from VR to flat ones, from AAA to indies, and it just works.
Maybe I spent 30min https://wiki.debian.org/NvidiaGraphicsDrivers months ago (years now? time flies) when I did my install and since then smooth sailing. I have minor issues, e.g. suspend sometimes hang. Sometimes coming back from sustain some visual glitches in the browser via WebGL, but that's it.
Edit: I sometimes also use the GPU for CUDA for local AI/LLM (mostly to make sure it's bullshit, and it is but at least I can say I tried) and that also went well, just followed instructions.