Honestly, the way I see it, it might be good to play something you are interested in keeping playing. It may be just my experience, but I see a lot of system and genre inertia, where the players aren't willing to switch systems that easily.

Familiarity with the world lore will be more important in the long run. In the short term, remember that players want to play, they want to buy into the world, or, as Matt Colville put it, they have "willing suspension of disbelief".

As a sidenote, if you want to play D&D 5e or similar tactical medieval fantasy games, i strongly suggest watching the Running the Game videos in Matt' YouTube channel (found here). Start from the beginning, he takes you step by step in designing a first dungeon to dip your toes in the DMing water.

Welcome to the hobby!