Here’s a little script I use for every fresh install I do. It isn’t ground breaking stuff, but it saves me the hassle of diving into settings and finding all the check boxes to check. Here it is:

# Set Gnome Clock to AM/PM Mode
gsettings set org.gnome.desktop.interface clock-format '12h'

# Enable Fractional Scaling
gsettings set org.gnome.mutter experimental-features "['scale-monitor-framebuffer']"

# Add Minimize and Maximize buttons
gsettings set org.gnome.desktop.wm.preferences button-layout ':minimize,maximize,close'

# Display Battery Percentage
gsettings set org.gnome.desktop.interface show-battery-percentage true

# Enable Tap to Click
gsettings set org.gnome.desktop.peripherals.touchpad tap-to-click true

# Enable Natural Scrolling
gsettings set org.gnome.desktop.peripherals.mouse natural-scroll true
gsettings set org.gnome.desktop.peripherals.touchpad natural-scroll true

# Install Flatpak
sudo apt install flatpak

# Add Flathub repository
flatpak remote-add --if-not-exists flathub https://flathub.org/repo/flathub.flatpakrepo

# Install GNOME Software plugin
sudo apt install gnome-software-plugin-flatpak

To finish making gnome into a comfortable home for me, I also manually install the dash-to-dock and blur my shell gnome extensions.

Also note that I used to run into a bug with some apps and the fractional scaling option turned on. Even with the scaling set to a round number, apps like Vivaldi would be blurry when fractional scaling was enabled. When I had that issue I'd disable it and use gsettings set org.gnome.desktop.interface text-scaling-factor 1.2 instead.