Casual Conversation

I haven't seen it before, is this the paper they are hinting at (I HATE it when articles don't mention the research they are talking about) https://doi.org/10.1242/dmm.050878 ?

The problem with this literature review is the studied studies only look at 30% total energy as LC, which on a 1500 kcal daily intake is 75g of carbs, which means the participants were not in a ketogenic state, not fat adapted, and had elevated insulin levels during the study. I think they looked at a weak signal across the data set, but that is the purpose of literature reviews.

I'm glad they are reviewing the Noakes literature. If you look at table 1, every low carbohydrate intervention regardless of fat composition resulted in a reduction of liver fat. That tells us saturated fat is not a independent variable in this review.

From the conclusion of the paper

Current evidence from hypercaloric feeding studies clearly shows that the consumption of excess calories, regardless of the macronutrient composition, increases IHTG content.

hypercaloric and isocaloric intervention studies in humans is that an individual’s dietary fat composition likely plays a role in mediating their IHTG content and composition

Likely tells us this is a opinion, and they qualified it in the expert opinion even.

Although the effect of SFA on IHTG content appears to diverge from that of unsaturated FA, specifically PUFA, the mechanisms underpinning these observations remain to be elucidated

Likely because this analysis isn't looking along insulin or ketogenic state. Probably because there is lots of paper competition, so taking a novel perspective has a better publication chance for a phd candidate.

It's a interesting literature review, but hardly a smoking gun against saturated fat as a demon, especially when you look at table 1 and the ketogenic interventions.

Please have a look at diet doctors literature review of saturated fat https://www.dietdoctor.com/low-carb/saturated-fat#evidence-to-date

It's extremely well referenced.