this post was submitted on 21 Jul 2025
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Metabolic Health

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A place to discuss metabolic health research, papers, talks, etc.

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Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high–glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic and genetic research provides mechanistic evidence in support of the CIM. In animals, dietary composition has been clearly demonstrated to affect metabolism and body composition, independently of calorie intake, consistent with CIM predictions. Meta-analyses of behavioral trials report greater weight loss with reduced-glycemic load vs low-fat diets, though these studies characteristically suffer from poor long-term compliance. Feeding studies have lacked the rigor and duration to test the CIM, but the longest such studies tend to show metabolic advantages for low-glycemic load vs low-fat diets. Beyond the type and amount of carbohydrate consumed, the CIM provides a conceptual framework for understanding how many dietary and nondietary exposures might alter hormones, metabolism, and adipocyte biology in ways that could predispose to obesity. Pending definitive studies, the principles of a low-glycemic load diet offer a practical alternative to the conventional focus on dietary fat and calorie restriction.

https://doi.org/10.1001/jamainternmed.2018.2933

Full Paper here

[Sorry to keep reposting this, I've had to move communities 3 times in the last month, it makes linking references a chore]

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[–] Valmond@lemmy.world 3 points 3 days ago (2 children)

Just to clarify: insulin is bad yes, but only because the body releases it as a response to high blood sugar levels (it is what controls the blood sugar levels and you can't live without it) which you got because of high sugar intake (or refined sugar intake).

So IMO it's sugar (raw, refined, etc) that's the culprit. I'm also a keto fan so take that information for what it is.

[–] xep@fedia.io 2 points 1 day ago

I think it's unusual to say that insulin is bad. Chronic insulin resistance is surely a sign of poor metabolic health, because it means that the body has had to secrete a lot of it to address persistently high levels of glucose in the bloodstream, which is caused by eating too much sugar in any of its forms. Sugar (and by extension carbohydrates) is what is bad.

Like you said, it's a critical hormone and we cannot function without it. T1D is an inability to secrete enough insulin and those affected waste away very quickly without medical aid.

[–] jet@hackertalks.com 3 points 3 days ago* (last edited 3 days ago) (1 children)

I'd add carbohydrates to the list of culprits. Sugar (raw, refined, etc) and Carbohydrates both end up in the blood stream as glucose, so as far as insulin response goes they are equivalent.

Can someone consume carbohydrates and maintain health? Sure! Is it helping them do so? not so much.

[–] Valmond@lemmy.world 3 points 3 days ago* (last edited 3 days ago)

Totally, pasta bread lots of stuff.

Edit: more refined sugars/carbs spikes the blood sugar levels more and makes a worse insulinet response though.