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Alán Aspuru-Guzik takes a lot of calls these days from scientists considering an exit from the United States. Aspuru-Guzik, a theoretical chemist, left Harvard University, in Cambridge, Massachusetts, during Donald Trump’s first term as US president, from 2017 to 2021, to join the University of Toronto in Canada and hasn’t looked back. “I’m the happiest guy here,” he says.

Here, Nature talks to Jones, Aspuru-Guzik and others who left during Trump’s first term about relocating and reshaping their careers. They have plenty of advice.