Is there a reason you're suspecting it wouldn't work?

No, not really. I was just wondering if that works too. I have an old PC with stand in my room and I must urgently upgrade the memory. For this I wanted to use hard drives, because they are cheaper.
I've been playing with the idea of getting something like a NAS for a while. And because I always find DIY cool I was wondering if others have already tried it with a framework.

I didn't consider that you can use the USB ports to connect hard drives. In my naivety I only thought about SATA ports.