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Framework Laptop 16: our exclusive hands-on - theverge.com
(www.theverge.com)
This is a most excellent place for technology news and articles.
In the article it mentioned that Framework isn't against third party mods like a swappable battery where the gpu slot goes. With this in mind, I'm sure there will be third party options with different mouse pads that actually have buttons.
Unless there physically isn't enough space.