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The lethal doses of 55 substances
(infosec.pub)
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this post was submitted on 25 Feb 2024
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Depends on the isotope, of course. There are different ways it can hurt you.
If you've got more than 52 kg of uranium 235 on your hands, I would be alarmed to learn you didn't understand how criticality worked. Although now that I think of it, there's probably an awful lot of people who indirectly handle that much when they move around a nuclear warhead and most of them probably only had a single lecture on the concept.
The thing that always blows my mind is just how freaking dense uranium is. A sphere weighing 52 kg is only 17 cm across.