Done this (kinda) before on a accord V6 so basically the same engine. Have to take the manifold off which is pretty straightforward. Don't drop anything inside or you'll have a bad day. Gaskets are pretty easy. Know your torque specs when you reassemble. Different bolts have different loads.

Spark plugs are right there too. Don't over crank or you'll have a bad day. These engines use coil-on-plug, so you don't have to replace wires. The ECU will tell you if it misfires anyway. Do not do not do not cheap out on spark plugs and get some crap Bosch bs to save a few bucks. Why do I know? It's called plug ejection and it leaves you stranded on the side of the road. The spark plug takes the cylinder threads with it as it's launched into space. I replaced all the plugs and 3 others were broken in some way. Don't be like me. Slapped NGK plugs in and not a problem since. Stick with those.

I will mention it would be a great time to check/adjust valve clearances especially if you are around 200,000 miles. Mine needed it pretty bad.

Upgrade-wise there is a manifold spacer which supposedly increases torque. Kinda wish I did that then (new gaskets needed) but I thought my car was on its last leg so I didn't want to throw cash at it. Surprise, reliable ever since.

Oh, and there is a gasket on the throttle body that is easy to tear. Be gentle and you can reuse it.