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Two tales of domestication
(lemmus.org)
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I mean, the cuter an animal is the more humans want it. Pugs might have health issues, but selective breeding has certainly made them very popular. That is, to the animals advantage.
Taking pugs as an example, being bred into an existence filled will medical issues that majorly impact your health and make living pain, it's certainly not an advantage. Sure, they're popular, but being popular is what drives them to be bred even more. The medical issues don't go away, though