I switched over from Win10 to PopOS! about a month ago. It hasn't been 100% painless but it's leaps and bounds better than the last time I tried to switch 5-10 years ago. For reference I'm in an AMD CPU and Nvidia GPU, NVME drives for both the system and game drives, SATA for a data drive, NAS for media. I've only reinstalled once because I broke everything tinkering with different desktop environments, but it was an easy recovery with the install media.

All the correct drivers were installed from the get go. I managed to overwrite my cloud save for Horizon Forbidden West because of an issue mounting my game drive and mapping the correct install location in Steam, but that was 90% on me because I rejected the idea of making a backup copy of the files because "I know what I'm doing". I ended up wiping my game drive entirely and reformatting it as EXT4 and haven't had any problems since - the drive was NTFS before and had a handful of games already installed from Windows.

A couple games require finding the right Proton version to run it, but GE works flawlessly for most things I've tried. Everything has run as fast or faster than in Windows with the exception of WH4K: Darktide. There's some microsecond delay in there somewhere that I couldn't pin down. Didn't seem to be video or network related. It's the kind of thing that I bet I wouldn't notice if it were my first time playing the game, but since I've got a couple hundred hours in it, it is just enough to throw me off and make me feel slightly drunk.