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This is a rule for help
(lemmy.ml)
DAE Speech 100 int 1 run
Alt text: A photo of the doge meme with the text "I am At a point in my life where I seek validation amongst my peers By discussing New Vegas on 196"
Not the ideal way to do it, but I literally just pirated the game [1] and installed it as a Windows application with stock WINE-staging. I then installed Vortex as a Windows application with stock WINE, installed some mods, and played some modded FNV on Linux. It played just as well on Linux as it did on Windows even with all the mods.
Point being, the way that worked best for me was to just treat it and all its mods as a Windows application and let stock WINE handle it for me.
[1] I purchased the game on Steam but I couldn't be arsed to find the Windows executables or get it to work with Steam and Proton.
Which Wine are you on? 9.x or a something downstream?
9.8 Staging currently. I'm on Debian, but I get WINE from the WineHQ repo.