The House of the Duke of Almodóvar del Río is a building built in Comillas between 1899-1902 by the architect from Jerez Francisco Hernández-Rubio y Gómez for Juan Manuel Sánchez y Gutiérrez de Castro and his wife Genoveva de Hoces y Fernández de Córdoba, Dukes of Almodóvar del Río and Marquises of Puebla de los Infantes.

It is a construction that can be stylistically classified as part of the so-called English historicist architecture and its characteristics include asymmetry, the multiplicity of axes and the wood and brickwork, features that contrast significantly with the styles of other notable buildings in Comillas such as the eclecticism of the Palacio de Sobrellano or the modernism of Gaudí's Capricho.