Fight what exactly? Determinism either is or isnt how the universe works, it isnt like some sort of external force of finite capacity that can be resisted by some application of effort. If it is true, then you have no choice but to act the way something like you would act, and the way humans are wired to think is in terms of choices and the possible outcomes of those choices, even if the choice you make and the thinking that leads you to it is inevitable. If it is not true, then the possibility of making different choices exists, but it doesnt look any different to you because you only get to perceive the result of following one set of them.
The thing about determinism is that while it may be an interesting philosophical exercise, beyond being difficult to maybe impossible to prove or disprove, it isnt really relevant to much. A deterministic universe looks, feels, and acts to us exactly like a nondeterministic one would.