Get any QMK board with enough keys and the other features you need, particularly if its got a VIA/VIAL config. It's inherently programmable (literally every key) and cross-platform. The "easy" answer here would be a Keychron, but there are others.
If you can drop in size just a touch, where you still have a numpad but a small number of keys are moved, removed, or resized, then there are many enthusiast and near-enthusiast boards with "96%" or "1800" layouts, the main difference being whether the arrows, F-row, and numpad are fully compacted into a rectangle or slightly separated to guide your hands.