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Best OS/setup for raid10 2x6tb and 2x12tb?
(alien.top)
You could do your ideal scenario with LVM or with linux mdraid.
I'm not too familar with ZFS so not sure if you could do it on ZFS.
If its primary purpose is a NAS, you should be using a NAS OS
I strongly question why UnRAID lets you do something that a purpose-built NAS OS, like TrueNAS Core, does not
Unraid does support unequally sized drives, your parity drive just needs to be as large as your largest drive. It's not true mirroring of course.
The easiest setup would be to create two RAID1 sets, this also gives your the highest chance of recovering data in case one or more drives die.
I would honestly just go with two separate mirrors unless you need performance (of course if all drives are CMR and on the same RPM level). With MDRAID or ZFS.