Playing around with different cab IRs was key for me to finding the best tones. Blending multiple IRs can be great too.
I use a pack where the SM57 IR is a bit too harsh and the R121 IR is a bit too boomy. Together they're beautiful.
Getting the appropriate input level is key too. From there, tweaking EQ can help a good amount.
I'd also recommend, if you've not already, trying out the Neural Amp Modeler. It's a bit like a Kemper Profiler but open source and plugin based. There's a website called Tonehunt full of captures by the community. There are some great options for tone there!