It's not a very good game, but I laughed my ass off through the Deadpool game. The one that immediately comes to mind though is Bulletstorm. It definitely set the bar for high-brow, sophisticated humor.It's a shame that People Can Fly chose to go with Outriders, because I'd kill for Bulletstorm 2.

Destroy All Humans 1&2 on PS2 & Xbox

The MLB Slugfest series. I don't even like baseball, but they'd sneak these one liners into regular commentary and it just killed me.

"Everyone that came out to the ballpark today is getting a free piece of sandpaper"

Whiplash back on PS2

Well that cheesy Deadpool game.

Nexomon: Extinction cracked me up pretty much throughout the entire game.

Disco Elysium is the most recent game that was just chock full of humor, though maybe not focused on it specifically... beyond that the only games I can even really think of that had a focus on comedy were the old LucasArts classics. Sam & Max, Full Throttle, Monkey Island... And Borderlands.

I was just thinking about how this doesn't seem to be a thing anymore. Where are the comedic oriented games? Why is everything so damn dark, and serious and brooding nowadays?

But I haven't played that Not-Really-Rick-and-Morty-shooter. I heard that was funny.