Engineering CADs and old peripherals with proprietary drivers for me. This cannot be always solved with a VM because either they are graphically intensive or hardware passthrough just doesn't work for them.
There's one specific case of Texas Instruments' software suite for microcontrollers: they have all the tools, the IDE and SDKs available for windows/mac/linux, EXCEPT one stupid old sdk I needed that was ONLY available on Windows for some reason, so I had to use it just for that stupid piece of drivers.
For games I either do games that work on proton, or for extreme cased I have a VM with second GPU in passthrough, and that works quite qell, but cannot do on a work laptop.
"No, we can't do anything to Russia, even if they are attacking our infrastructure and provoking a military response, that could be seen as an escalation!"
Meanwhile, Russia escalating infrastructure attacks and military provocations.