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You know CO (carbon monoxide) is treated just like oxygen by the body but the brain doesn’t realize it’s not getting the oxygen you just pass out. It’s the reason why people die by accident, the body just breaths like normal.
Same thing for nitrogen, or any gas besides CO2. The human body has no way to detect oxygen. It can only detect CO2.
Not relevant to the argument at hand, but the body does have low O2 detection. I’ve held my breath with a pulse oximeter on before, and while high CO2 makes you panic, when you get to about 87% your body has a response I would describe as “breathe, mother fucker” which is hard to ignore. COPD patients often regulate using this hypoxic drive.
If you hold your breath the CO2 accumulates in your blood, making it acidic and triggering the "breathe, mother fucker" reflex.
You need to exhale the CO2 without inhaling O2 for the body to not realize it.