Not exactly the same thing (though it's as close as you can get currently without surgery), but I used to wear circle lenses.

People were either wholly freaked out by it, loved it, or thought I was on drugs. No in-betweens, really.

If you've seen the big eyes on the thumbnails for the "Pitch Meeting" videos on Youtube, which kind of look similar to Anime Eyes: yes, they do look horrifying.

It would look fine...