RPGMemes

Most liquid in a human is not water and a human is not an open container.

Create Water cannot create water in midair, and I don't think Enlarge/Reduce can target a blob of liquid. If you did manage to do this (ie. Create Water into a tub above the enemy, enlarge/reduce it (assuming the water would enlarge too), and dump it on the enemy, you could probably rule it as the same effect as a Tidal Wave spell if you want it to work that way. You'd need a lot of water though.