this post was submitted on 24 Sep 2025
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Hey guys. I'm in peri and am on progesterone 300mg nightly and estradiol 0.025mg patches twice weekly. My nipples are unbelievably sore. Seriously they feel like fresh bruises, even the pressure of fabric from a shirt or bra can be painful. My GYN said this is common with progesterone and recommended evening primrose pills, but like an idiot I didn't ask what strength or how often. Do you have any experience with this or advice? Please and thanks - it's making me extremely cranky 😬

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[–] dandelion@lemmy.blahaj.zone 3 points 3 days ago* (last edited 3 days ago) (1 children)

that's weird, progesterone has a pretty short half-life (oral prog has a half life of 16 - 18 hours), after a day or two I would think the dose you took would be fully out of your system 🤔 typically progesterone is prescribed and taken daily (usually every night, since it can create sleepiness).

[–] SharkWeek@lemmy.blahaj.zone 3 points 3 days ago (1 children)

I was put on it quite a few years ago, maybe the normal dosages etc have changed. All I know is that one week on / one week off doesn't result in me having trouble sleeping, and I have a reasonable amount of energy :-)

My wife is now peri and going through all kinds of period fuckery, her doctor told her if she wanted HRT she'd have to go work it out in her own.

I love how consistent women's healthcare is :-/

[–] dandelion@lemmy.blahaj.zone 3 points 3 days ago (1 children)

100 - 200 mg is about the same dose most people take AFAIK (I personally take 100 mg / night). I find I only really need prog to help me sleep when my estrogen is high, so when my estrogen is waning I skip my prog doses and I sleep fine.

For the on week, are you taking it every night for a week, and then taking a week off without it? That's super interesting!

My wife is now peri and going through all kinds of period fuckery, her doctor told her if she wanted HRT she’d have to go work it out in her own.

I love how consistent women’s healthcare is :-/

And yeah, I'm regularly pissed when I hear how gynecologists are treating their patients - refusing to take blood tests for symptoms of low estrogen because of birth control (and offering nothing), not taking symptoms seriously, not being proactive and helpful to ensure obvious signs of low estrogen aren't treated ... it's so common and predictable, it's hard not to see medicine as inherently sexist, tbh.

[–] SharkWeek@lemmy.blahaj.zone 2 points 3 days ago

Sometimes I have one day without it in the middle of the week, but it's a bit easy to loose track.

The idea of a lower dose every day sounds really appealing, consistency would be nice! I'll ask the pharmacy about getting some 100mg next time I run out - thanks, I haven't thought about changing it for ages and there's no harm in trying :-)