this post was submitted on 24 Sep 2025
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Advice for nipple pain? (startrek.website)
submitted 3 days ago by klemptor@startrek.website to c/womensstuff@piefed.blahaj.zone
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Hey guys. I'm in peri and am on progesterone 300mg nightly and estradiol 0.025mg patches twice weekly. My nipples are unbelievably sore. Seriously they feel like fresh bruises, even the pressure of fabric from a shirt or bra can be painful. My GYN said this is common with progesterone and recommended evening primrose pills, but like an idiot I didn't ask what strength or how often. Do you have any experience with this or advice? Please and thanks - it's making me extremely cranky 😬

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[–] dandelion@lemmy.blahaj.zone 4 points 3 days ago* (last edited 3 days ago)

prog definitely helps with sleep for most folks

I have to take my prog rectally, it turns out the liver filters out most of it when taken orally and you get very little increase in blood levels as a result (read more here), so you might consider trying 100 - 200 mg rectally and see if that helps the sleep issue for you. Personally I find oral is less effective for my sleep than rectal administration, but that varies significantly from person to person.

Night sweats and brain fog screams low estrogen, though - I would have tried increasing estrogen for those symptoms, not progesterone. Maybe see if you could get a cream that would allow you some flexibility in dose timing and amount, then once you know what works you would know a better long term stable dose for your patches. Sometimes low enough estrogen can cause sleep problems too, so it may not be a problem solved by taking more prog if you just need a bit more estrogen.

I'm so sorry you're going through this, but I'm also happy you're staying invested in finding a solution and not just trying to tough it out 💖