this post was submitted on 24 Sep 2025
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Hi, I took my first estradiol cypionate injection this Sunday after staring at the bottle for about a month and I've been experiencing some muscle soreness since. I just want to make sure I haven't fucked up something beyond repair, and it would be nice to talk to some humans about this rather than just following directions off the internet. I'll include my process at the bottom but if someone can tell me "no that happens to everyone, you're good" it would really help me. I understand there's a lot more that goes into DIY HRT and I'm working towards that too.

Injection process I followed for scientific rigor:

SpoilerI followed the directions as well as I understood it: using a luer lock syringe, I drew 0.1 mL from my vial using, I think it was a 22 gauge needle, after wiping it down with an alcohol pad, then realized I wasn't going to get that amount out of the syringe due to drawing it incorrectly or some other mishap, so I drew more of the solution, about 1.5 mL. I swapped the needle out for a 25 gauge, 1.5 inch needle which was recommended for intramuscular injections, then I stared at the needle for about ten minutes trying to keep my hands from shaking due to a currently very inconvenient phobia of them, then injected the solution into basically the meatiest part of my glute. I'm underweight, so I assume my options for injections are fairly limited. No bleeding occurred, and the injection site looks like a small red pock currently

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[–] clay_pidgin@sh.itjust.works 4 points 1 day ago (3 children)

Makes sense! If you're aware of the risks (I have no idea what they might be) then I think it's your business. I was imagining OP in the kitchen with a Bunsen burner and a smoking Erlenmeyer flask!

[–] hedgehog@ttrpg.network 5 points 1 day ago

Now I’m imagining Breaking Bad but making E instead of Meth.

[–] WalrusDragonOnABike@reddthat.com 2 points 1 day ago (1 children)

Some people do start with raws and do sterilization while missing with the oils for doing the injection, which involves some extra equipment (although some people may already have it lying around in their kitchen). Self-injection is the norm AFAIK.

[–] clay_pidgin@sh.itjust.works 1 points 1 day ago

Thank you for the detail.

[–] mossy_@lemmy.world 2 points 1 day ago

dude I wish. amateur alchemy might be in the future for me but for now I'm taking whatever help I can get