It's mostly the non-humanoid bosses that take a few tries just to understand their attack patterns. The humanoid dudes got spongey, but I haven't died to them yet. There's also the RNG upgrade bits that can make it easier or harder. I got lucky and have basically infinite ammo and I gain back health as I deal damage with those. It just doesn't help when you die because the Eldritch horror you have to look up at to make sure you're not slapped is also breaking the floor below you and you fall through into the void. lol

Totally just a skill issue on my part.