Depends on the game.

Monster hunter: they get the cute armor sets. Dudes get the fat armor sets, while that version of the lady armor is something like a mecha teddy bear.

Social games: I aim for the more gender neutral looks, and for whatever reason guys are almost always bulky. It's usually somewhat possible to get a female avatar to look guyish. And if it's using voice chat, there is very little question.

Online MMOs: I have set male and female character tropes/character types that have been developed for 20ish years at this point. Coskii is an axe welding merchant or as close to that as I can manage. My thief is a lady, archer is a guy, wizard is a guy, and sorcerer is lady.

Single player whatevers: it depends on the character sounds. Sometimes games can get a bit excessive with their sound design, and for whatever reason make the guy voice sound like he's constipated for every sound effect.