Well, not really. Oklahoma is a deeply red state, but it is more liberal in areas like Oklahoma City, Tulsa, and the university towns. I've always gotten the impression that people living in the panhandle were a different breed of conservative psycho though.

Like all states, there is a gradient of political leanings, especially around cities. For instance, northern Virginia is nothing like the rest of Virginia at all. I imagine it's similar in Oklahoma, where the major population centers don't reflect the rest of the state at all.