thus saying "so-and-so is the way it is because we live in a simulation" would be a moot remark.

Not quite.

For example, in Minecraft it approximates aspects of this world, but because of processing capabilities isn't doing so at the same fidelity.

So people in Minecraft discussing why everything is made up of giant blocks would probably get great value out of the realization that they are in a simulation of a higher fidelity world that needed to be rendered at a lower fidelity for processing reasons. Scientists in Minecraft could further their understanding of the rules governing it likely much more successfully if they also understood the why directing the how.

A simulation is generally unlikely to be an exact replica of the universe simulating it, even if attempting to be a representative digital twin.