Cutting the caulking tube tip is very important. If all the gaps are big, cut it so the hole is big. If they are small, cut it small. Cut it at an angle because you don't use it straight on. If it is water based, have a bucket filled with water and a couple drops of dish soap. Put one or more rags in the water depending on how much caulking you have to do. The water and soap are there so it won't stick to your hand and fingers as badly. Keep as clean as you can. I used to have to use cases of white lightning to caulk millwork and French doors on new McMansions several times a week. If it's not water based, use acetone or denatured alcohol depending. The tip cutting is still very important no mater what solvent or water is being used. Too small is better than too big.