I'd be okay with picking up SGU where it left off, using the cryosleep break as an opportunity to recast and retool as needed. I think the show's first season was weak but it was really picking up and getting interesting in the second season. I can think of a bunch of interesting directions things could go from there.

Of course, everything is predicated on "is the writing good?" If you have good writing you can make something awesome out of almost any premise. And if it's bad event the best premise won't save you. It's even worse when it's bad writing on a good premise because it "ruins" it for future attempts.