Artemis III, the first manned flight to the lunar surface, has serious outstanding logistical issues that need to be addressed before flight can even be considered.

Eh, for better or for worse, the entire Artemis program was kind of designed to be "politically incancellable", not an "efficient lunar exploration program". Some of the logistical issues (like Gateway) are a "feature, not a bug".

Further discussion of Destin's video was had over in this thread.