They aren’t really incompatible in game. For Vampires, a Lupine should be an OH FUCK OH SHIT OH FUCK tier enemy to most parties, either a run (smart) or fight as a team (good luck) encounter.

Yeah. One time in tt, our malk and a setite met one on the Santa Monica pier. Malk got a miraculous 8 successes on Athletics to get away (took a picture of it), while the setite did the smart thing and dove into the water.

Did your Toreador solo a lupine by themselves? Were they a powerful Elder, or the world’s luckiest roller?

Not an elder, but a martial artist with max Celerity. Still lost though, because at the time I sucked at challenges.