I would argue that nearly no one finds this one funny but many found this one funny

The OP comic is less accessible than the empiricism one, so the target audience is smaller, some of the smaller audience comics required one knew Firefly, open source memes, and Corey Doctorow. When you're in the target group the comics are especially hilarious

Some have fallen flat for me until I looked up XKCD explained, since I have very low knowledge of pop culture. I wouldn't say those aren't funny, I say I don't get them