Identifying when to throw those last few hit points in the trash and call the fight a "win" for the adventurers is part of what separates a great GM from a good GM.
Your games pacing, the spotlight moment for your heavy hitters, and respecting your players time and emotional investment in a combat scene, are all much more important than the big bads last 10 HP.
Sigourney Weaver has been a prolific swamp dancer ever since she did Gorillas in the Mist back in '88. If she wants to grace your swamps with her dance, you let her. It's an honor.