I had never heard of Waterfox before seeing this post. I went and checked it out. Basically, their "thing" seems to be that they have Firefox's privacy settings automatically defaulted to stronger settings, yet still mild enough for normal web browsing (it won't break as many websites as when you have Firefox fired up on all privacy cylinders, I guess?).
They also have incognito tabs instead of just incognito windows.
Other than that, I don't see any differences in the GUI for ease of use.
You have to be ok with believing that you're not annoying others when talking about yourself and asking about them. And you have to do it in a not-creepy way. I haven't quite figured it out yet.