Works on the AMD Pro series GPUs and my 6800xt on Pop OS

Sure, you can use a VPN if you want to spin up the instance and connect to it without having a domain. You can always open the instance of Nextcloud to the internet later, when you buy a domain.

Get a cheap .XYZ domain if you just want to experiment with spinning up a reverse proxy.

Honestly I think they can and should be compared, they're both distros after all.

What distro/software are you using?

There's a small amount of telemetry going on.

Also, Pop_OS makes running an Nvidia GPU less painful.