this post was submitted on 24 Sep 2025
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Advice for DIY self injections (lemmy.world)
submitted 2 days ago* (last edited 2 days ago) by mossy_@lemmy.world to c/mtf@lemmy.blahaj.zone
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Hi, I took my first estradiol cypionate injection this Sunday after staring at the bottle for about a month and I've been experiencing some muscle soreness since. I just want to make sure I haven't fucked up something beyond repair, and it would be nice to talk to some humans about this rather than just following directions off the internet. I'll include my process at the bottom but if someone can tell me "no that happens to everyone, you're good" it would really help me. I understand there's a lot more that goes into DIY HRT and I'm working towards that too.

Injection process I followed for scientific rigor:

SpoilerI followed the directions as well as I understood it: using a luer lock syringe, I drew 0.1 mL from my vial using, I think it was a 22 gauge needle, after wiping it down with an alcohol pad, then realized I wasn't going to get that amount out of the syringe due to drawing it incorrectly or some other mishap, so I drew more of the solution, about 1.5 mL. I swapped the needle out for a 25 gauge, 1.5 inch needle which was recommended for intramuscular injections, then I stared at the needle for about ten minutes trying to keep my hands from shaking due to a currently very inconvenient phobia of them, then injected the solution into basically the meatiest part of my glute. I'm underweight, so I assume my options for injections are fairly limited. No bleeding occurred, and the injection site looks like a small red pock currently

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[–] Cassa@lemmy.blahaj.zone 5 points 2 days ago (1 children)

(I'll start off by saying no expert here - began this year myself)

I do Subcutaneous injections and I can get a stiff sore spot - that looks red and can be felt. it goes away around after a week.

I might be misreading but how much did you inject? 1.6ml? was there any air or bubbles inside the syringe when you injected?

[–] mossy_@lemmy.world 3 points 1 day ago (1 children)

I used a calculator on the internet to see how much solution I would need to inject to get the desired dose and I believe it was 0.1 mL. Due to the size of my syringe, when I drew that amount the first time I wasn't able to get any of the solution out of it, I depressed the plunger to the end just getting the air out. So I drew a bit more and some of it stayed in the syringe. I probably ended up with a little more than I had planned but not 60% more

[–] Witchfire@lemmy.world 7 points 1 day ago* (last edited 1 day ago)

I've been doing this shit for years. Here is my process

  1. Wash your hands thoroughly
  2. Clean vial and skin with iso
  3. Fill syringe with air (I'd say about double your dose)
  4. Stab into vial and inject air into vial
  5. Flip upside down and draw dose
  6. Take out, draw air into the syringe
  7. Swap out your needles
  8. Push out air until a bead forms at the tip
  9. Stabby stab and push
  10. Treat with alcohol pad and bandaid
  • I know some people purposefully use an air bubble to push out the full amount but that's riskier so I don't recommend it
  • Soreness is normal. Sometimes it happens sometimes it doesn't.
  • Don't EVER reuse needles and dispose of them in a hard plastic container (get a sharps container if you don't have one)
  • Disclaimer: I'm not medically trained, I'm just a trans kinkster and sideshow performer