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I haven’t combined them directly, but I have taken both Sertraline and bupropion at different stages in my life. I agree that Sertraline eventually takes a toll on your libido, smothering it like a wet blanket over a fire. I can also attest to some people having an increase in anxiety with bupropion because that shit made me want to claw my skin off. I always felt like I was seconds away from exploding while I was on it. It’s difficult to describe. I stopped taking it after a few weeks because it made me an edgy mess.
To overcome the lack of libido on Sertraline I just “practiced” by trying to initiate intimacy with my partner (or myself), even when I didn’t feel like it, because eventually I could “get in the mood” and it became easier over time after reminding my body that it was, in fact, fun to have sex. I also noticed increasing my activity level by working out a few times a week helped quite a bit with increasing my libido.
Eventually after changing jobs, finding a good workout regimen, and reducing my alcohol intake, I was able to get off the Sertraline and my libido came back after a few weeks.
That’s just my experience though, I wish you the best of luck.
I had a similar experience. The sertraline helped with anxiety/depression but did lower libido. Finding alternative strategies for the anxious or depressive moments and weaning off the sertraline helped in the long-run. I think using a counselor to dive more into understanding why you feel anxious or depressed in that moment could be helpful to finding a strategy without medication (or at least as much) if they’re having unwanted effects.
For instance, I had pretty bad anxiety when I people whispering. It made me think they were talking badly about me and I felt bad about myself. I eventually realized with a counselor that had low self confidence and reminded myself of the mantras that helped me through that specific moment. “They probably have a million other things to talk about other than you. What they’re saying is not meant for your ears. And even if they are, they’re opinion has no bearing on your worth as a person.”