I play games on PS5, Switch, and Mac Mini.

On consoles, I use gamepad, usually with back buttons / paddles. Nothing interesting.

On my Mac Mini, I mostly play emulated games and point and click games.

• For emulated games, mostly using gamepad, except for shmups, fighting games, and arcade MAME games, which I use my Hori Mini Fighting Stick
• For point and click games, Civ, and OpenRA, I use a cheap Huion drawing tablet
• I don't play much FPS, but the last one I played was TimeWarpers (an idle FPS game), and I managed to use a trackball to play it comfortably

I switched from right hand mouse to left hand trackball (It's Kensington Expert trackball, not really right or left handed) earlier this year, because my right hand was aching. I thought it was RSI, but now when I think about it, it might have been uric acid.