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Potential DLC Hooks in Wither's party
(ttrpg.network)
Baldur’s Gate 3 is a story-rich, party-based RPG set in the universe of Dungeons & Dragons, where your choices shape a tale of fellowship and betrayal, survival and sacrifice, and the lure of absolute power. (Website)
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In my playthrough Karlach is a mindflayer and her engine is no longer an issue, so I can't see that working for everyone, lol.
I was working under the assumption the player kept Karlach alive and un-mind flayered, it's possible she never even made it to the end because Wyll killed her or the player committed some good old tiefling genocide and she left. The very idea of a DLC is honestly incredibly unlikely, but if one did happen and it wasn't just some unrelated story, resolving Karlach's engine troubles is probably the least convoluted one to implement.