MSF and Heifer International I think are two of the more unimpeachable charities afaik

I feel like I've also heard nothing but good things about Habitat for Humanity

Planned Parenthood imo is a great cause as well. Or IPPF internationally.

These are partially listed as strong examples because they are considered very good charities that help people but also because of the aid multiplication effect of them. Charities that provide stop gap aid are important but not at the expense of aid that provides knock on effects. Ie. More homes and shelter and more sustainable living leads to less poverty down the road, less crime, less broken homes etc... Helping the sick and injured removes need for intensive long term care by family and hopefully produces a new productive person who can help their community. Heifer International helps establish agricultural infrastructure that the locals own and operate themselves, not just feeding people. And perhaps most critically of all, Planned Parenthood gives women the right to take care of their bodies and make choices on it. A woman who grows up healthy and has choices gets more educated and doesn't make unplanned children that nobody is ready to care for properly. This has incredibly positive affects not just on the women's lives but on society down the road. Simple birth control/sexual health access produces incredible ripple effects in society, better educated women, better educated children, less poverty, lower crime.