Well if you mean creatively, there's lots of options. But yes, using a complete void of audio can also be an intentional creative choice to force you to feel certain things, I believe 2001 did this for a lot of the external space shots. Cut to black endings to a lot of movies use an empty block of audio too as a punctuation.

A lot of other movies/shows use a lot of different creative options. Like if you're exposed in space you'd hear your heart and blood pressure sky rocket before stopping, maybe your last breath of oxygen molecules vibrating in your cranium like The Expanse did. You could maybe create the sound of an exposed star bombarding you too. Star Trek often uses ambient engine noises or their ships to fill any empty space in the mix. Another common example is if you're in a space suit, you'd hear the internal machines and your heartbeat would be super loud. All of these are creative choices of course and not meant to be realistic, which nothing really is meant to be in a movie mix.

It should be the sound of the machines on board, but now I also wonder what is used