Ah my solution to this is different: if the things that I use to protect my shit are blocking some $x, ah well that can just get fucked then

Too exhausted by all the bullshit to try debug someone’s fuckery and specialcase them. Only exception is if it’s something I need (and then I’ll do so very grumpily, and quite possibly loudly)

elaborating on that. when you can hit a protein cleanly (without some side effects (called off-target, there are also on-target side effects)) but you hit wrong protein, this doesn't have to be a complete loss, but it's likely. maybe you learn something, either about biology of that all or about something else that it interacts with, or maybe you have found a cure to some other disease instead. but this is the actual hard problem of drug development, especially when the biology of it all is little known. there's a few of these drugs that started this way, fentanyl, viagra, thalidomide (as anticancer), minoxidil come to mind, and at worst you have a new tool for biologists. alphafold won't help with that