27
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
this post was submitted on 05 May 2024
27 points (100.0% liked)
TechTakes
1489 readers
30 users here now
Big brain tech dude got yet another clueless take over at HackerNews etc? Here's the place to vent. Orange site, VC foolishness, all welcome.
This is not debate club. Unless it’s amusing debate.
For actually-good tech, you want our NotAwfulTech community
founded 2 years ago
MODERATORS
also note that the big failures come from faulty biology, not from faulty chemistry. You can set innumerable piles of cash on fire if you choose to plug a wrong enzyme
elaborating on that. when you can hit a protein cleanly (without some side effects (called off-target, there are also on-target side effects)) but you hit wrong protein, this doesn't have to be a complete loss, but it's likely. maybe you learn something, either about biology of that all or about something else that it interacts with, or maybe you have found a cure to some other disease instead. but this is the actual hard problem of drug development, especially when the biology of it all is little known. there's a few of these drugs that started this way, fentanyl, viagra, thalidomide (as anticancer), minoxidil come to mind, and at worst you have a new tool for biologists. alphafold won't help with that