Py2wasm?

You're broadly going to have a bad time trying to force the wrong language for the job, fwiw.

You could always stop doing web frontend dev - there's plenty of other stuff in programming to do. If you're into UI dev, then modern native mobile dev runs on either Kotlin for Android or Swift for iOS, both of which are highly competent languages. Their modern UI toolkits are Jetpack Compose for Android and SwiftUI for iOS, both of which are reactive in the style of React, but unburdened by the shortcomings of JavaScript.

There have been attempts. With WebASM. There's even an interesting compiler for it. Not super fast, but potentially useful. Good luck with gaining traction though. https://wasmer.io/posts/py2wasm-a-python-to-wasm-compiler

Django?

random duck results include many sites claiming things like:

Convert your Python Code to Javascript. This exceptional AI-powered tool converts your Python code into Javascript code easily, eliminating the need for manual re-coding. Save your precious time and unlock cross-platform development like never before with our converter tool

what could possibly go wrong?

• https://pyodide.org/

• https://pyscript.com/

• https://github.com/brython-dev/brython

Isn't this what NaCl and WebAssembly was supposed to allow?

This will become increasingly realistic as WebAssembly matures. In the meantime, my out-of-left-field suggestion is to check out ClojureScript.

Not as popular as it used to be, but I still maintain some CoffeeScript apps... even write new code in it.

https://coffeescript.org/#introduction

You still have to know JS, but you might find it more palatable this way.

python is worse than js, imo