The Jellyfin streaming has been designed with HTTP so I don't think it will benefit from a TCP proxy. Plus as you've noticed with TCP you lose the ability to route by domain name.
TCP streams don't have any concept of hostname.
I would test it both ways and see if there's actually a measurable difference. I have Jellyfin behind Traefik and I don't have issues.
Also, Jellyfin docs do have a page on using nginx: https://jellyfin.org/docs/general/networking/nginx
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