fullsquare

the deal:

none of these are complete without posadism

So far I've only read Harry Potter and The Methods of Rationality, but can say it is an excellent place to start.

beware the man of one book

Who does this appeal to? It's nonsense.

the fake nerds of silicon valley of course

it got better over course of the day, maybe just it needed some time

it looked the same in jerboa (current) and in firefox on linux, comparing to another instance where i also have an account. also some crossposts were missing, but now all are in place. seems like some of these communities weren't subscribed from this instance before. part of the rest was different sorting method (hot vs active)

for now it works, but i'll look up if i can find an example

on reddit, the website plays you

have rules never clearly explained, get banned pretty much immediately. a taste of real reddit experience™ even that i've never got banned sitewide (only on r/conservative) i guess you win if you touch grass or quit

death of millions for profit - solid business practice, congratulations and see you again at next shareholder meeting

I'm with the old man on this one. Antibodies can clear out amyloid and still it has no effect on progression of disease, amyloid secretion can be blocked upstream (like with small molecule protease inhibitors) and it still has no effect. Maybe this one hits something off-target, or maybe that effect is not even real, or maybe it's some sort of statistical artifact. You'd stumble upon some false positive after trying so many times.

Aducanumab is dead in the water, trials shown no effect and it was abandoned by Biogen. This one is about lecanemab. Both have massive problems with brain edema and microhemorrages, which probably means these are not suitable for actual use. But don't worry, they already have received their reward - FDA wanted to have something, anything to show up for Alzheimer and Biogen cashed in when stock price went up

think cold fusion, or EmDrive, or string theory

That's a weird set - cold fusion or EmDrive can be tested and their physical principles are falsifiable - and they were - but string theory is different, because it's not falsifiable.

If it’s marginally but truly effective,

That if makes some mighty heavy lifting here. I think that amyloid hypothesis is closer to cold fusion than to string theory in that it had already a couple of fatal experimental refutations thrown at it, but people still shove effort this way because there's nothing else/copium/sunk cost combination

that's just internet dementia

has he? where?

Derek Lowe casually points to Yarvin and Thiel in his writeup on how trumpists are destroying american science, in part 7 specifically. nrx have fully broke containment